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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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1-Ethyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → 7-(3-Ethenyl-1-piperazinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

HRID 248522
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인쇄 미리보기

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HRID 248522 반응식
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:14])=[C:10](F)[CH:11]=2)[C:6](=[O:15])[C:5]([C:16]([OH:18])=[O:17])=[CH:4]1)[CH3:2].[CH:19]([CH:21]1[NH:26][CH2:25][CH2:24][NH:23][CH2:22]1)=[CH2:20]>N1C=CC=CC=1>[CH:19]([CH:21]1[NH:26][CH2:25][CH2:24][N:23]([C:10]2[CH:11]=[C:12]3[C:7]([C:6](=[O:15])[C:5]([C:16]([OH:18])=[O:17])=[CH:4][N:3]3[CH2:1][CH3:2])=[CH:8][C:9]=2[F:14])[CH2:22]1)=[CH2:20]
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참가 물질

4

반응물 2

HCID 8005211-Ethyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidHCID 153829012-Ethenylpiperazine

생성물 1

HCID 197635327-(3-Ethenyl-1-piperazinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid수율 12.2%

시약·촉매·용매 1

HCID 1049Pyridine용매

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온도
100 °C

실험 절차

A mixture of 1.2 g of 1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, 1.9 g of 3-ethenylpiperazine and 15 ml of pyridine is heated at 100° C. in a pressure bottle for 3 hours, then cooled and evaporated. The residue is purified by silica gel flash chromatography, eluting with chloroform:methanol:water:triethylamine (9:0.5:0.02:0.02), giving 200 mg of the desired product.

후처리

  1. temperaturecooled
  2. customevaporated
  3. customThe residue is purified by silica gel flash chromatography
  4. washeluting with chloroform:methanol:water:triethylamine (9:0.5:0.02:0.02)

출처 및 근거

ORD 기록
ord-27d2872add054c3ea3fd49c3ad32de46
출처 데이터셋
uspto-grants-1993_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05210193

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