Aluminium lithium hydride → 1-Methyl-3-(thiophen-3-yl)piperazine
반응식
[S:1]1[CH:5]=[CH:4][C:3]([CH:6]2[NH:11][CH2:10][CH2:9][N:8]([C:12](OCC)=O)[CH2:7]2)=[CH:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>CCOCC>[CH3:12][N:8]1[CH2:9][CH2:10][NH:11][CH:6]([C:3]2[CH:4]=[CH:5][S:1][CH:2]=2)[CH2:7]1참가 물질
4
실험 절차
A solution of 1.20 g of 3-(3-thienyl)-1-piperazine carboxylic acid, ethyl ester in 100 ml of ether was added to a suspension of 380 mg of lithium aluminum hydride in 50 ml of ether. The mixture was refluxed for 12 hours and the product recovered, giving 850 mg of 4-methyl-2-(3-thienyl)piperazine.
후처리
- temperatureThe mixture was refluxed for 12 hours
- customthe product recovered
출처 및 근거
- ORD 기록
- ord-271a57d9d7e84be39fb2694ca37e1fa0
- 출처 데이터셋
- uspto-grants-1993_05
- 특허 번호
- US05210193
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