Potassium Iodide → Diethylaminocarbonylmethyl 3-[(2-acetylthiomethyl-3-phenylpropionyl)amino]benzoate

HRID 248702

반응식

HRID 248702 반응식
[C:1]([S:4][CH2:5][CH:6]([CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:7]([NH:9][C:10]1[CH:11]=[C:12]([CH:16]=[CH:17][CH:18]=1)[C:13]([OH:15])=[O:14])=[O:8])(=[O:3])[CH3:2].[I-].[K+].C(N(CC)CC)C.Cl[CH2:36][C:37]([N:39]([CH2:42][CH3:43])[CH2:40][CH3:41])=[O:38]>CN(C=O)C.O>[C:1]([S:4][CH2:5][CH:6]([CH2:19][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[C:7]([NH:9][C:10]1[CH:11]=[C:12]([CH:16]=[CH:17][CH:18]=1)[C:13]([O:15][CH2:36][C:37]([N:39]([CH2:42][CH3:43])[CH2:40][CH3:41])=[O:38])=[O:14])=[O:8])(=[O:3])[CH3:2]

참가 물질

7

반응물 4

HCID 4875Potassium IodideHCID 8471TriethylamineHCID 16844Chloro-N,N-diethylacetamideHCID 10215552Benzoic acid, 3-[[2-[(acetylthio)methyl]-1-oxo-3-phenylpropyl]amino]-

생성물 1

HCID 15670248Diethylaminocarbonylmethyl 3-[(2-acetylthiomethyl-3-phenylpropionyl)amino]benzoate수율 74.9%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

3-[(2-Acetylthiomethyl-3-phenylpropionyl)amino]-benzoic acid (compound of Example 68-(b)-[1]) (0.72 g) and potassium iodide (0.37 g) are dissolved in DMF, and thereto are added triethylamine (0.2 g) and 2-chloro-N,N-diethylacetamide (0.33 g) with stirring at room temperature, and the mixture is reacted three nights. The reaction mixture is mixed with water and extracted with ethyl acetate. The extract is washed with water, dried over anhydrous magnesium sulfate, and ethyl acetate is distilled off under reduced pressure. The residue is purified by a medium pressure column chromatography using silica gel (eluant, chloroform). The fractions containing the desired compound are collected, and chloroform is distilled off under reduced pressure to give the title compound (0.71 g). m.p.: 143°-144° C. (amorphous) IR (KBr; cm-1): 1725, 1690, 1635

후처리

  1. customthe mixture is reacted three nights
  2. extractionextracted with ethyl acetate
  3. washThe extract is washed with water
  4. dry with materialdried over anhydrous magnesium sulfate, and ethyl acetate
  5. distillationis distilled off under reduced pressure
  6. customThe residue is purified by a medium pressure column chromatography
  7. additionThe fractions containing the desired compound
  8. customare collected
  9. distillationchloroform is distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-bd327e3a4f3a4b43ac7cc8bcd61a6a65
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05210266

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