Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 3-[4-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]benzoylamino]-3-methoxycarbonylpropionic Acid Methyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | L-Aspartic acid, 1,4-dimethyl ester, hydrochloride (1:1) | HCID 2734892 | — |
| 반응물 | 4-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl)benzoic acid | HCID 3699990 | — |
| 반응물 | HCID 178526939 | HCID 178526939 | — |
| 생성물 | 3-[4-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]benzoylamino]-3-methoxycarbonylpropionic Acid Methyl Ester | HCID 54299813 | — |
반응 단계
Under the conditions of Example 2(a), 3.633 g (10 mmol) of 4-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl]benzoic acid, 1.836 g (10 mmol) of L-aspartic acid dimethyl ester hydrochloride, 1.531 g (10 mmol) of hydroxybenzotriazole, hydrate, as well as 1.012 g (10 mmol) of triethylamine and 2.063 g (10 mmol) of dicyclohexylcarbodiimide are reacted and worked up analogously. The crude product is chromatographed on silica gel. The title compound is eluted with ethyl acetate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05210290 |
| 출처 데이터셋 | uspto-grants-1993_05 |
| ORD ID | ord-c3d11d6747d84941bceeabe889f74077 |
| 출처 메모 | uspto-grants-1993_05 |