Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Catechol → 2-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-benzodioxole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Catechol | HCID 289 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | 1-(4-(Trifluoromethyl)phenyl)ethan-1-one | HCID 69731 | — |
| 반응물 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-benzodioxole | HCID 18961198 | — |
반응 단계
A solution of catechol (5.5 g) and 4-(trifluoromethyl)acetophenone (10.3 g) in toluene (150 ml) containing a catalytic amount (0.2 g) of p-toluenesulphonic acid monohydrate was heated under reflux for 3 days. Water produced in the condensation was separated by means of a Dean-Stark trap. After removal of the solvent under reduced pressure, the residue was purified by chromatography on silica gel using methylene chloride as eluant. Pure 2-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-benzodioxole was obtained as a colourless oil (10.8 g, 77%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05212171 |
| 출처 데이터셋 | uspto-grants-1993_05 |
| ORD ID | ord-0dd0d6cfe8b34810b23f92ec85f99d7e |
| 출처 메모 | uspto-grants-1993_05 |