참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | 3-(4-Fluorophenyl)-2-propenoic acid | HCID 98070 | — |
| 반응물 | Glycine methyl ester hydrochloride | HCID 122755 | — |
| 반응물 | Glycine,n-(1-oxo-3-phenyl-2-propen-1-yl)-, methyl ester | HCID 582979 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-Fluorocinnamoyl-glycine methyl ester | HCID 53656853 | — |
반응 단계
Following the general procedure described in example 1, step 2, for cinnamoyl-glycine methyl ester, glycine methyl ester hydrochloride (7.5 g) was suspended in tetrahydrofuran, cooled to 0° C., treated with N-methylmorpholine (8.4 ml, 1 equivalent), followed immediately by a precooled solution of 4-fluorocinnamic acid (10.0 g) in tetrahydrofuran, which had been pre-activated by treatment with dicyclohexylcarbodiimide (12.4 g, 1 equivalent) and 1-hydroxybenzotriazole (9.2 g). After work-up, 4-fluorocinnamoyl-glycine methyl ester was obtained as a white solid which was used for the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05212158 |
|---|
| 출처 데이터셋 | uspto-grants-1993_05 |
|---|
| ORD ID | ord-c99bff5c88ba41f8bd02708dafbd874d |
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| 출처 메모 | uspto-grants-1993_05 |
|---|
