Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methylmorpholine → Glycine,n-(1-oxo-3-phenyl-2-propen-1-yl)-, methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | 2-Propenoic acid, 3-phenyl- | HCID 8784 | — |
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | Glycine methyl ester hydrochloride | HCID 122755 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Glycine,n-(1-oxo-3-phenyl-2-propen-1-yl)-, methyl ester | HCID 582979 | — |
반응 단계
Cinnamic acid (38.0 g) was coupled to glycine methyl ester hydrochloride in dimethylformamide by treatment with dicyclohexylcarbodiimide (52.84 g) and 1-hydroxybenzotriazole (39.24 g), followed by N-methylmorpholine (37.56 ml). The reaction mixture was stirred overnight at room temperature and then worked up in the usual manner to give the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05212158 |
| 출처 데이터셋 | uspto-grants-1993_05 |
| ORD ID | ord-ecf315e47df3405c9faf417599866d90 |
| 출처 메모 | uspto-grants-1993_05 |