Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Phenylacetyl-glycine-t-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Phenylacetic Acid | HCID 999 | — |
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | Isobutyl chloroformate | HCID 62365 | — |
| 반응물 | Glycine tert-butyl ester | HCID 151417 | — |
| 반응물 | Benzoyl-glycine-t-butyl ester | HCID 11020853 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Phenylacetyl-glycine-t-butyl ester | HCID 19762247 | — |
반응 단계
Following the procedure described for benzoyl-glycine-t-butyl ester, a solution of phenylacetic acid (11.44 grams) in ethyl acetate (approx. 100 ml) was activated by the mixed anhydride method using N-methylmorpholine (11.66 ml) followed by isobutyl chloroformate (10.89 ml) at -20° C. and coupled with glycine t-butyl ester.HCl (14.04 g) in methylene chloride (approx. 150 ml) which had been neutralized by addition of N-methylmorpholine (11.66 ml). After work-up, the product was obtained as an oil which was used for the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05212158 |
| 출처 데이터셋 | uspto-grants-1993_05 |
| ORD ID | ord-788a972defb74bada23a51c3657af5e9 |
| 출처 메모 | uspto-grants-1993_05 |