Dicyclohexylcarbodiimide → N-(2-diethylaminoethyl)-N-(ethyl)-((1R,3R,4S)-1-methyl-4-isopropylcyclohex-3-yloxy)acetamide

참여 물질

역할	이름	HCID	투입량
반응물	Dicyclohexylcarbodiimide	HCID 10868	—
반응물	Triethylethylenediamine	HCID 66040	—
반응물	2-[[(1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl]oxy]acetic acid	HCID 7018861	—
용매	Tetrahydrofuran	HCID 8028	—
생성물	N-(2-diethylaminoethyl)-N-(ethyl)-((1R,3R,4S)-1-methyl-4-isopropylcyclohex-3-yloxy)acetamide	HCID 57193064	60.4%

반응 단계

5.0 g of ((1R,3R,4S)-1-methyl-4-isopropylcyclohex-3-yloxy)acetic acid were dissolved in 100 ml of tetrahydrofuran. 3.4 g (=4.2 ml) of N,N,N'-triethylethylenediamine and 5.3 g of dicyclohexylcarbodiimide were added to the solution, and the reaction mixture was stirred at room temperature for 24 hours. The mixture was worked up by concentrating it under reduced pressure. The remaining residue was purified by chromatography on silica gel using dichloromethane/methanol as the eluent. 4.8 g of N-(2- diethylaminoethyl)-N-(ethyl)-((1R,3R,4S)-1-methyl-4-isopropylcyclohex-3-yloxy)acetamide were obtained.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US05212173
출처 데이터셋	uspto-grants-1993_05
ORD ID	ord-5a73f691c0374498be7d2285e48061d9
출처 메모	uspto-grants-1993_05