Thionyl Chloride → 3-(1-Adamantyl)-4-methoxybenzoyl chloride

HRID 249024

반응식

HRID 249024 반응식
[C:1]12([C:11]3[CH:12]=[C:13]([CH:17]=[CH:18][C:19]=3[O:20][CH3:21])[C:14](O)=[O:15])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.S(Cl)([Cl:24])=O>>[C:1]12([C:11]3[CH:12]=[C:13]([CH:17]=[CH:18][C:19]=3[O:20][CH3:21])[C:14]([Cl:24])=[O:15])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 52965033-(1-Adamantyl)-4-methoxybenzoic acid

생성물 1

HCID 108044973-(1-Adamantyl)-4-methoxybenzoyl chloride수율 100%

실험 절차

In a round bottom flask, there are introduced 200 ml of thionyl chloride and there are then added, in small fractions, 35 g (122 mmoles) of the acid obtained in stage (a), above. The reaction mixture is heated to reflux until the emission of gases ceases. The reaction mixture is evaporated to dryness, taken up in 100 ml of anhydrous benzene and again evaporated to dryness, yielding 37 g of the expected product (100% yield) having a melting point of 153°-154° C.

후처리

  1. temperatureThe reaction mixture is heated
  2. temperatureto reflux until the emission of gases ceases
  3. customThe reaction mixture is evaporated to dryness
  4. customagain evaporated to dryness

출처 및 근거

ORD 기록
ord-19110497a281468ea9a9a7cea488f338
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05212203

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