Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 2-amino-6-chloro-9-(beta-D-xylofuranosyl)purine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | N-(6-chloro-7H-purin-2-yl)acetamide | HCID 6098997 | — |
| 반응물 | 2,3,5-tri-O-acetyl-beta-D-ribofuranosylpurine | HCID 69884339 | — |
| 촉매 | Mercurous Chloride | HCID 24182 | — |
| 생성물 | 2-amino-6-chloro-9-(beta-D-xylofuranosyl)purine | HCID 14284102 | — |
반응 단계
The chloromercury derivative of 2-acetamido-6-chloropurine is condensed with 2,3,5-tri-O-acetyl-β-D-ribofuranosylpurine utilizing the method of Lee et. al. (1971), J. Med. Chem., 14:819. The condensation product was treated with ammonia to yield 2-amino-6-chloro-9-(β-D-xylofuranosyl)purine. Further treatment with sodium hydroxyethylmercaptide gives the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05212295 |
| 출처 데이터셋 | uspto-grants-1993_05 |
| ORD ID | ord-c337ce6791bb4561b9d6b1749ed0dbdb |
| 출처 메모 | uspto-grants-1993_05 |