참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Urea | HCID 1176 | — |
| 반응물 | 3-Aminopyridine-2-carbonitrile | HCID 577015 | — |
| 용매 | Diethylene Glycol Monoethyl Ether | HCID 8146 | — |
| 생성물 | 4-Amino-pyrido[2,3-e]pyrimidin-2-one | HCID 19366879 | — |
반응 단계
A slurry of 3-Amino-2-cyanopyridine (200 mg) and urea (400 mg) in 2-(2-ethoxyethoxy)ethanol (0.5 mL) was gradually heated to about 205° C., and maintained at 205° C. for 10 min. Heating was ceased and 6 mL of hot water was carefully added while shaking the mixture. The mixture was vacuum filtered to collect the precipitate. The precipitate was washed with water and ethyl acetate and allowed to dry to yield 4-Amino-pyrido[2,3-e]pyrimidin-2-one as a light yellow solid, m.p. >300° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05212310 |
|---|
| 출처 데이터셋 | uspto-grants-1993_05 |
|---|
| ORD ID | ord-8c8abec0a7934af8a15f606f2ba90a6a |
|---|
| 출처 메모 | uspto-grants-1993_05 |
|---|
