Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 4-(4-Nitro-benzyl)-thiomorpholine 1,1-dioxide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Nitrobenzyl bromide | HCID 66011 | — |
| 반응물 | Thiomorpholine 1,1-dioxide | HCID 6484228 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 4-(4-Nitro-benzyl)-thiomorpholine 1,1-dioxide | HCID 22569762 | — |
반응 단계
8.6 g (40 mmol) of 4-nitrobenzylbromide are dissolved in 100 ml of acetone. 6.9 g (50 mmol) of potassium carbonate and 5.4 g (40 mmol) of thiomorpholine-1,1-dioxide are added. The reaction solution is stirred for 7 hours at ambient temperature. After the undissolved solids have been filtered off, the solution is concentrated by evaporation. The residue is divided between ethyl acetate and water. The organic phases are freed from solvent in vacuo. The product is triturated with ether and dried.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06855710B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-b6d7314026c24c77bd7ca76677a3d6c5 |
| 출처 메모 | uspto-grants-2005_02 |