Potassium Carbonate → 4-(4-Nitro-benzyl)-thiomorpholine 1,1-dioxide

HRID 24919

반응식

HRID 24919 반응식
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Br)=[CH:6][CH:5]=1)([O-:3])=[O:2].C(=O)([O-])[O-].[K+].[K+].[NH:18]1[CH2:23][CH2:22][S:21](=[O:25])(=[O:24])[CH2:20][CH2:19]1>CC(C)=O>[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8][N:18]2[CH2:23][CH2:22][S:21](=[O:25])(=[O:24])[CH2:20][CH2:19]2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 660114-Nitrobenzyl bromideHCID 6484228Thiomorpholine 1,1-dioxide

생성물 1

HCID 225697624-(4-Nitro-benzyl)-thiomorpholine 1,1-dioxide

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

8.6 g (40 mmol) of 4-nitrobenzylbromide are dissolved in 100 ml of acetone. 6.9 g (50 mmol) of potassium carbonate and 5.4 g (40 mmol) of thiomorpholine-1,1-dioxide are added. The reaction solution is stirred for 7 hours at ambient temperature. After the undissolved solids have been filtered off, the solution is concentrated by evaporation. The residue is divided between ethyl acetate and water. The organic phases are freed from solvent in vacuo. The product is triturated with ether and dried.

후처리

  1. filtrationAfter the undissolved solids have been filtered off
  2. concentrationthe solution is concentrated by evaporation
  3. customThe product is triturated with ether
  4. customdried

출처 및 근거

ORD 기록
ord-b6d7314026c24c77bd7ca76677a3d6c5
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855710B2

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