Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Anthranilic Acid → 1,2,3,3a-Tetrahydro-3a-phenyl-5H-pyrrolo[1,2-a]-3,1-benzoxazin-5-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Anthranilic Acid | HCID 227 | — |
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | 4-Chlorobutyrophenone | HCID 253533 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | 1,2,3,3a-Tetrahydro-3a-phenyl-5H-pyrrolo[1,2-a]-3,1-benzoxazin-5-one | HCID 19761077 | — |
반응 단계
A mixture of 26.1 g of 2-aminobenzoic acid, 36.5 g of 4-chloro-1-phenyl-1-butanone, 0.5 g of p-toluenesulfonic acid and 250 ml of xylene were refluxed with a water trap. After the reaction was complete, the solvent was removed by distillation and the remaining solid was recrystallized from ethanol. Yield: 41.1 g (81.5%), melting point 152° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05214047 |
| 출처 데이터셋 | uspto-grants-1993_05 |
| ORD ID | ord-db75a1b05ccf4cf8acdc118e9f3e2955 |
| 출처 메모 | uspto-grants-1993_05 |