Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Nitrobenzaldehyde → 4-(Azetidin-1-yl-methyl)-nitrobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Nitrobenzaldehyde | HCID 541 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 반응물 | Azetidine hydrochloride | HCID 12308726 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 4-(Azetidin-1-yl-methyl)-nitrobenzene | HCID 22569653 | — |
반응 단계
6.2 g (41 mmol) of 4-nitrobenzaldehyde and 3.8 g (40.6 mmol) of azetidine-hydrochloride are dissolved in 120 ml of ethanol. 2.6 g (41 mmol) of sodium cyanoborohydride are added at 0° C. The mixture is slowly heated to ambient temperature and then stirred for 18 hours. Then the solvent is eliminated in vacuo, the residue is taken up in ethyl acetate and washed with water. The solvent is eliminated in vacuo and after chromatography of the residue on silica gel (ethyl acetate/methanol/NH4OH=95:5:0.5) a light brown oil is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06855710B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-ebebe92616344816b517ea4dc75ba6dd |
| 출처 메모 | uspto-grants-2005_02 |