Acetic Acid → HCID 15017643, 화합물
반응식
[CH3:1][N:2]([CH3:11])[C:3]1[S:4][CH:5]=[C:6]([CH2:8][CH2:9][NH2:10])[N:7]=1.C=O.[C:14](O)(=O)C>O.CO>[CH3:11][N:2]([CH3:1])[C:3]1[S:4][C:5]2[CH2:14][NH:10][CH2:9][CH2:8][C:6]=2[N:7]=1참가 물질
6
실험 절차
2-Dimethylamino-4-(2-aminoethyl)thiazole (1.7 g, see preceding preparation), formaldehyde (0.78 ml of a 37% solution in water, 9.6 mmol) and acetic acid (0.15 ml, 2.6 mmol) were combined in methanol (100 ml). After 2.5 hours at room temperature, the reaction mixture was treated with additional formaldehyde (0.15 ml, 1.8 mmol) and allowed to stir for an additional 16 hours. The reaction was then filtered, and the filtrate was concentrated in vacuo and purified by column chromatography (eluant: 89:10:1 of chloroform:methanol:concentrated ammonium hydroxide), providing the title product as a white solid (1.04 g, 5.7 mmol).
후처리
- filtrationThe reaction was then filtered
- concentrationthe filtrate was concentrated in vacuo
- custompurified by column chromatography (eluant: 89:10:1 of chloroform:methanol:concentrated ammonium hydroxide)
출처 및 근거
- ORD 기록
- ord-cba5fcd9d46d46cdb9c7eca0684ae0fa
- 출처 데이터셋
- uspto-grants-1993_05
- 특허 번호
- US05214051
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