Phenacylamine → 2-Aminoacetophenone 4-chlorophenylhydrazone

HRID 249317노트

반응식

HRID 249317 반응식
[NH2:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18][NH2:19])=[CH:14][CH:13]=1>CCO.CC(O)=O.O>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18][N:19]=[C:3]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:2][NH2:1])=[CH:14][CH:13]=1

참가 물질

6

반응물 2

HCID 11952PhenacylamineHCID 70624(4-Chlorophenyl)hydrazine

생성물 1

HCID 867463512-Aminoacetophenone 4-chlorophenylhydrazone수율 84%

시약·촉매·용매 3

HCID 176Acetic Acid용매HCID 702Ethanol용매HCID 962Water용매

실험 절차

A mixture of 10.43 g 2-aminoacetophenone and 11.0 g 4-chlorophenylhydrazine in 30 ml EtOH and 10 ml HOAc was refluxed for one hour. The cooled reaction mixture was diluted with water and the precipitate was collected, washed with water, and dried to give 16.83 g solid. Recrystallization from methanol gave 3.48 g solid, m.p. 109°-112° C.

후처리

  1. temperaturewas refluxed for one hour
  2. customThe cooled reaction mixture
  3. customthe precipitate was collected
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-fd729e02bed74f7e97efb42406945fc6
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05214059

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