Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Propanesulfonyl chloride → Isopropylsulphonic acid-(4-tert.butoxycarbonylamino-phenyl)-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Propanesulfonyl chloride | HCID 82408 | — |
| 반응물 | tert-Butyl (4-aminophenyl)carbamate | HCID 688611 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | Isopropylsulphonic acid-(4-tert.butoxycarbonylamino-phenyl)-amide | HCID 22569426 | — |
반응 단계
1.2 g (10 mmol) of isopropylsulphonic acid chloride are added dropwise to a solution of 1.0 g (4.8 mmol) of 4-tert.butoxycarbonylamino-aniline in 10 ml of pyridine. The mixture is stirred for 18 hours at ambient temperature. Then the reaction solution is poured onto 150 ml of ice water and then extracted with ethyl acetate. The organic phases are washed with water and freed from solvent. The residue is chromatographed on silica gel (dichloromethane/methanol/NH4OH=19:1:0.1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06855710B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-da9825c092654534b8c9572e9d0b2491 |
| 출처 메모 | uspto-grants-2005_02 |