Ammonia → 2-Amino-4-fluoro-6-trifluoromethoxy-1,3,5-triazin
반응식
[NH3:1].F[C:3]1[N:8]=[C:7]([F:9])[N:6]=[C:5]([O:10][C:11]([F:14])([F:13])[F:12])[N:4]=1>O1CCCC1>[NH2:1][C:3]1[N:8]=[C:7]([F:9])[N:6]=[C:5]([O:10][C:11]([F:14])([F:13])[F:12])[N:4]=1참가 물질
4
반응 조건
- 온도
- -70 °C
실험 절차
4.4 g (0.259 mol) of gaseous ammonia were passed over the course of 45 minutes into a stirred mixture of 26.0 g (0.1293 mol) of 2,4-difluoro-6-trifluoromethoxy-1,3,5-triazine and 100 ml of tetrahydrofuran at -70° to -65° C. The mixture was then stirred for 2 hours at -70° C. and overnight while warming to 22° C. The residue from concentration under reduced pressure was stirred with water, filtered off with suction and washed. Drying yielded 22 g (85.9% of theory) of the title compound of melting point 138°-139° C.
후처리
- temperaturewhile warming to 22° C
- concentrationThe residue from concentration under reduced pressure
- stirringwas stirred with water
- filtrationfiltered off with suction
- washwashed
- customDrying
출처 및 근거
- ORD 기록
- ord-6e72e2ebf2b944b187676f3cbe556459
- 출처 데이터셋
- uspto-grants-1993_05
- 특허 번호
- US05214143
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