Sodium Methoxide → 2-Amino-4-methoxy-6-trifluoromethoxy-1,3,5-triazine
반응식
[CH3:1][O-:2].[Na+].[NH2:4][C:5]1[N:10]=[C:9](F)[N:8]=[C:7]([O:12][C:13]([F:16])([F:15])[F:14])[N:6]=1>CO>[NH2:4][C:5]1[N:10]=[C:9]([O:2][CH3:1])[N:8]=[C:7]([O:12][C:13]([F:16])([F:15])[F:14])[N:6]=1참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
9.1 g (0.0505 mol) of 30% strength sodium methylate were added over the course of 15 minutes to a stirred mixture of 10 g (0.0505 mol) of 2-amino-4-fluoro-6-trifluoromethoxy-1,3,5-triazine and 100 ml of methanol at 0° C. The mixture was stirred at 0° C. for one hour and then concentrated under reduced pressure, taken up in methylene chloride and extracted with water. Drying and concentration yielded 10.5 g (99% of theory) of the title compound of melting point 96°-101° C.
후처리
- concentrationconcentrated under reduced pressure
- extractionextracted with water
- customDrying
- concentrationconcentration
출처 및 근거
- ORD 기록
- ord-a242ac4ad4d0450f98e28732b68067a0
- 출처 데이터셋
- uspto-grants-1993_05
- 특허 번호
- US05214143
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