Di-p-toluoyltartaric acid → 8-Methoxy-2-aminotetralin

반응식

C1(C)C=CC(C(C(C(O)=O)(O)C(C(C2C=CC(C)=CC=2)=O)(O)C(O)=O)=O)=CC=1.[CH3:29][O:30][C:31]1[CH:32]=[CH:33][CH:34]=[C:35]2[C:40]=1[CH2:39][CH:38]([NH:41]CC1C=CC=CC=1)[CH2:37][CH2:36]2>>[CH3:29][O:30][C:31]1[CH:32]=[CH:33][CH:34]=[C:35]2[C:40]=1[CH2:39][CH:38]([NH2:41])[CH2:37][CH2:36]2

참가 물질

반응물 2

HCID 12049127Di-p-toluoyltartaric acid

HCID 12741413N-benzyl-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

생성물 1

HCID 101979338-Methoxy-2-aminotetralin

실험 절차

The resolution is performed on 8-methoxy-2-(benzylamino)tetralin with the aid of (-)-di-p-toluoyltartaric acid according to Karlsson, et al., Acta Chem. Scand., B 42, 231-236 (1988). The enantiomers of 8-methoxy-2-(benzylamino)tetralin are debenzylated, yielding the corresponding enantiomers of 8-methoxy-2-aminotetralin, i.e., R-(+)- and S-(-)-8-methoxy-2-aminotetralin.

출처 및 근거

ORD 기록: ord-e358c11ee4ab4afeb9c488842b9140a4
출처 데이터셋: uspto-grants-1993_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05214156

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