5-Methylisatin → Oxindole
반응식
N(C1C=C(N2CCOCC2)N=C(OCCN2CCOCC2)N=1)N.C[C:25]1[CH:26]=[C:27]2[C:31](=[CH:32][CH:33]=1)[NH:30][C:29](=[O:34])[C:28]2=O>C(O)(=O)C.C(O)C>[NH:30]1[C:31]2[C:27](=[CH:26][CH:25]=[CH:33][CH:32]=2)[CH2:28][C:29]1=[O:34]참가 물질
5
반응 조건
- 온도
- 60 °C
실험 절차
4-[2-(4-Hydrazino-6-(morpholin-4-yl)-pyrimidin-2-yloxy)-ethyl]-morpholine (80 mg; ¼ mmol) was added to a flask along with 5-methylisatin (53 mg; ⅓ mmol) and ethanol (4 mL). One drop of acetic acid was added, and the reaction was stirred overnight at 60° C. The mixture was then filtered and the precipitate was washed with ethanol (1 mL) and dried to give 5-methyl-3-{[6-morpholin-4-yl-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-hydrazono)}-1,3-dihydro-indol-2-one.
후처리
- filtrationThe mixture was then filtered
- washthe precipitate was washed with ethanol (1 mL)
- customdried
출처 및 근거
- ORD 기록
- ord-80fbb6712d6c4bc482b20d03dde24791
- 출처 데이터셋
- uspto-grants-2011_01
- 특허 번호
- US07863270B2
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