Dicyclohexylcarbodiimide → Ethyl 3-imino-5-methoxy-2,3-dihydroimidazo[1,5-a]pyridine-7-carboxylate

HRID 249734

반응식

HRID 249734 반응식
[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[C:10]([O:12][CH3:13])[N:9]=[C:8]([CH2:14][NH:15][C:16]([NH:18]C(OCC2C3C=CC=CC=3C3C2=CC=CC=3)=O)=S)[CH:7]=1)=[O:5])[CH3:2].C1CCC(N=C=NC2CCCCC2)CC1>C1(C)C=CC=CC=1>[NH:18]=[C:16]1[N:9]2[C:10]([O:12][CH3:13])=[CH:11][C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])=[CH:7][C:8]2=[CH:14][NH:15]1

참가 물질

4

반응물 2

HCID 10868DicyclohexylcarbodiimideHCID 57791304N-(4-Ethoxycarbonyl-6-methoxypyridin-2-ylmethyl)-N'-(fluoren-9-ylmethyloxycarbonyl)thiourea

생성물 1

HCID 178469329Ethyl 3-imino-5-methoxy-2,3-dihydroimidazo[1,5-a]pyridine-7-carboxylate수율 15.7%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

1.17 g (2.38 mmol) of N-(4-ethoxycarbonyl-6-methoxypyridin-2-ylmethyl)-N′-(fluoren-9-ylmethyloxycarbonyl)thiourea (20e) were treated with 491 mg (2.38 mmol) of DCC in 25 ml of toluene and refluxed for six hours. After standing overnight at RT, the mixture was freed from the solvent and the residue was chromatographed on silica gel (heptane/ethyl acetate 75:25→ethyl acetate/methanol 90:10), it being possible to isolate 88 mg of the title compound.

후처리

  1. temperaturerefluxed for six hours
  2. customthe residue was chromatographed on silica gel (heptane/ethyl acetate 75:25→ethyl acetate/methanol 90:10), it

출처 및 근거

ORD 기록
ord-26a9d4dd61c04d089dbadc506405d775
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863269B2

연결된 노트

불러오는 중…