Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrazine → Pyrimidine-4-carbohydrazide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrazine | HCID 9321 | — |
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | 4-Pyrimidinecarboxylic acid | HCID 169306 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Pyrimidine-4-carbohydrazide | HCID 468664 | — |
반응 단계
To a solution of pyrimidine-4-carboxylic acid (1.0 g, 8.0 mmol) in THF (15 mL), N,N-Carbonyldiimidazole (1.4 g, 8.9 mmol) was added. After refluxing for 2 hours, hydrazine (0.8 g, 20 mmol) was added to the reaction mixture slowly with a syringe at 0° C. The reaction mixture was allowed to warm to room temperature slowly and then concentrated to yield the desired product as white solid. LCMS calculated for C5H7N4O (M+H): 139.1. found: 139.1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07863285B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-295e910fa0114ff3a389fbb08f41978a |
| 출처 메모 | uspto-grants-2011_01 |