(3S)-1-azabicyclo[2.2.2]octan-3-amine dihydrochloride → (S)-N-(quinuclidine-8-yl)-2-(phenylamino) benzoxazole-4-carboxamide

HRID 249831

반응식

HRID 249831 반응식
[C:1]1([NH:7][C:8]2[O:9][C:10]3[C:11](=[C:13]([C:17]([OH:19])=O)[CH:14]=[CH:15][CH:16]=3)[N:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.Cl.[NH2:22][C@H:23]1[CH:28]2[CH2:29][CH2:30][N:25]([CH2:26][CH2:27]2)[CH2:24]1>>[N:25]12[CH2:24][C@@H:23]([NH:22][C:17]([C:13]3[CH:14]=[CH:15][CH:16]=[C:10]4[O:9][C:8]([NH:7][C:1]5[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=5)=[N:12][C:11]=34)=[O:19])[CH:28]([CH2:29][CH2:30]1)[CH2:27][CH2:26]2

참가 물질

3

반응물 2

HCID 12494973(3S)-1-azabicyclo[2.2.2]octan-3-amine dihydrochlorideHCID 668739882-(Phenylamino)benzoxazole-4-carboxylic acid

생성물 1

HCID 86623718(S)-N-(quinuclidine-8-yl)-2-(phenylamino) benzoxazole-4-carboxamide

실험 절차

Following general procedure GP-C1, A mixture of 2-(phenylamino)benzoxazole-4-carboxylic acid and (S)-(−)-3-aminoquinuclidine dihydrochloride were coupled to provide (S)—N-(quinuclidine-8-yl)-2-(phenylamino) benzoxazole-4-carboxamide, which was converted to the hydrochloride salt following general procedure GP-D1. 1H NMR and MS consistent.

출처 및 근거

ORD 기록
ord-4806df97d27f4a738f260cf462630a73
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863271B2

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