Dichloromethane → (S)-N-(quinuclidine-8-yl)-2-(2-methylpiperazin-1-yl)benzoxazole-4-carboxamide Dihydrochloride

HRID 249840노트

반응식

[CH3:1][CH:2]1[N:7]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[C:13]([C:17](=[O:27])[NH:18][CH:19]4[CH:24]5[CH2:25][CH2:26][N:21]([CH2:22][CH2:23]5)[CH2:20]4)[C:11]=3[N:12]=2)[CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.C(O)(C(F)(F)F)=O.C(Cl)[Cl:43]>>[ClH:43].[ClH:43].[N:21]12[CH2:20][CH:19]([NH:18][C:17]([C:13]3[CH:14]=[CH:15][CH:16]=[C:10]4[O:9][C:8]([N:7]5[CH2:6][CH2:5][NH:4][CH2:3][C@@H:2]5[CH3:1])=[N:12][C:11]=34)=[O:27])[CH:24]([CH2:23][CH2:22]1)[CH2:25][CH2:26]2

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 66874421HCID 66874421, 화합물

생성물 1

HCID 66874654(S)-N-(quinuclidine-8-yl)-2-(2-methylpiperazin-1-yl)benzoxazole-4-carboxamide Dihydrochloride

실험 절차

To an ice-cold solution of tert-butyl 3-methyl-4-(4-(quinuclidine-8-ylcarbamoyl)benzoxazole-2-yl)piperazine-1-carboxylate. (90 mg, 0.19 mmol) in CH2Cl2 (5 mL) was added TFA(0.25 mL, 3.2 mmol). The reaction mixture was stirred at room temperature for 12 h, and then concentrated under reduced pressure. The resulting TFA salt was converted to (S—N-(quinuclidine-8-yl)-2-(2-methylpiperazin-1-yl)benzoxazole-4-carboxamide dihydrochloride following GP-D1. 1H NMR and MS consistent.

후처리

concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록: ord-b5af2954dba04464ad1b0ef889d5d773
출처 데이터셋: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07863271B2

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