Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hexane → (RS)-S-[3-({[4-(Cyclobutylamino)-6-methoxyquinazolin-7-yl]oxy}methyl)phenyl]-N-(ethoxycarbonyl)-S-methylsulphoximide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hexane | HCID 8058 | — |
| 반응물 | Cyclobutylamine | HCID 75645 | — |
| 반응물 | Dichloromethane methanol | HCID 21226129 | — |
| 반응물 | N'-(2-cyano-5-{3-[(RS)-N-(ethoxycarbonyl)-S-methylsulphonimidoyl]benzyloxy}-4-methoxyphenyl)-N,N-dimethylformimidamide | HCID 57788001 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (RS)-S-[3-({[4-(Cyclobutylamino)-6-methoxyquinazolin-7-yl]oxy}methyl)phenyl]-N-(ethoxycarbonyl)-S-methylsulphoximide | HCID 57788036 | 74% |
반응 단계
According to GWP 5, the reaction of N′-(2-cyano-5-{3-[(RS)-N-(ethoxycarbonyl)-S-methylsulphonimidoyl]benzyloxy}-4-methoxyphenyl)-N,N-dimethylformimidamide (72 mg, 0.16 mmol) with cyclobutylamine (16 μL, 0.19 mmol) and chromatographic purification (silica gel, amino column, hexane, dichloromethane/methanol: 0→5% methanol) gives the desired product in 74% yield (56 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07863283B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-d7cc002d82424ac98a57459d0b68d588 |
| 출처 메모 | uspto-grants-2011_01 |