Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Aminopyridine → (RS)-N-(Ethoxycarbonyl)-S-methyl-S-[3-({[6-methoxy-4-(4-pyridylamino)-quinazolin-7-yl]oxy}methyl)phenyl]sulphoximide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Aminopyridine | HCID 1727 | — |
| 반응물 | Hexane | HCID 8058 | — |
| 반응물 | Dichloromethane methanol | HCID 21226129 | — |
| 반응물 | N'-(2-cyano-5-{3-[(RS)-N-(ethoxycarbonyl)-S-methylsulphonimidoyl]benzyloxy}-4-methoxyphenyl)-N,N-dimethylformimidamide | HCID 57788001 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (RS)-N-(Ethoxycarbonyl)-S-methyl-S-[3-({[6-methoxy-4-(4-pyridylamino)-quinazolin-7-yl]oxy}methyl)phenyl]sulphoximide | HCID 57787969 | 34% |
반응 단계
According to GWP 5, the reaction of N′-(2-cyano-5-{3-[(RS)-N-(ethoxycarbonyl)-S-methylsulphonimidoyl]benzyloxy}-4-methoxyphenyl)-N,N-dimethylformimidamide (78 mg, 0.12 mmol) with 4-aminopyridine (19 mg, 0.20 mmol) and chromatographic purification (silica gel, amino column, hexane, dichloromethane/methanol: 0→5% methanol) gives the desired product in 34% yield (29 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07863283B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-b56ba5c07a0a40c78eb7b9b8dd8d2362 |
| 출처 메모 | uspto-grants-2011_01 |