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Hexane → (RS)-S-[3-({[6-Methoxy-4-(1,3,4-thiadiazol-2-ylamino)quinazolin-7-yl]oxy}-methyl)phenyl]-S-methylsulphoximide

HRID 249942
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HRID 249942 반응식
C(OC([N:6]=[S:7]([CH3:35])([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][O:16][C:17]2[CH:26]=[C:25]3[C:20]([C:21]([NH:27][C:28]4[S:29][CH:30]=[N:31][N:32]=4)=[N:22][CH:23]=[N:24]3)=[CH:19][C:18]=2[O:33][CH3:34])[CH:10]=1)=[O:8])=O)C.[O-]CC.[Na+].CCCCCC.ClCCl.CO>CO>[CH3:34][O:33][C:18]1[CH:19]=[C:20]2[C:25](=[CH:26][C:17]=1[O:16][CH2:15][C:11]1[CH:10]=[C:9]([S:7]([CH3:35])(=[NH:6])=[O:8])[CH:14]=[CH:13][CH:12]=1)[N:24]=[CH:23][N:22]=[C:21]2[NH:27][C:28]1[S:29][CH:30]=[N:31][N:32]=1
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참가 물질

6

반응물 4

HCID 8058HexaneHCID 2723922Sodium ethoxideHCID 21226129Dichloromethane methanolHCID 57788000(RS)-N-(Ethoxycarbonyl)-S-methyl-S-[3-({[6-methoxy-4-(1,3,4-thiadiazol-2-ylamino)quinazolin-7-yl]oxy}methyl)phenyl]sulphoximide

생성물 1

HCID 57788009(RS)-S-[3-({[6-Methoxy-4-(1,3,4-thiadiazol-2-ylamino)quinazolin-7-yl]oxy}-methyl)phenyl]-S-methylsulphoximide수율 35%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

According to GWP 6, the reaction of (RS)-N-(ethoxycarbonyl)-S-methyl-S-[3-({[6-methoxy-4-(1,3,4-thiadiazol-2-ylamino)quinazolin-7-yl]oxy}methyl)phenyl]-sulphoximide (37 mg, 0.072 mmol) with sodium ethoxide (25 mg, 0.39 mmol) and chromatographic purification (silica gel, hexane, dichloromethane/methanol: 0→15% methanol) gives the desired product in 35% yield (11 mg).

출처 및 근거

ORD 기록
ord-ab768e0c7e1741d5851b6ea756d7c4cf
출처 데이터셋
uspto-grants-2011_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07863283B2

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