Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Aminobenzonitrile → (RS)-S-{3-[({4-[(3-Cyanophenyl)amino]-6-methoxyquinazolin-7-yl}oxy)methyl]-phenyl}-N-(ethoxycarbonyl)-S-methylsulphoximide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Aminobenzonitrile | HCID 16702 | — |
| 반응물 | N'-(2-cyano-5-{3-[(RS)-N-(ethoxycarbonyl)-S-methylsulphonimidoyl]benzyloxy}-4-methoxyphenyl)-N,N-dimethylformimidamide | HCID 57788001 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | (RS)-S-{3-[({4-[(3-Cyanophenyl)amino]-6-methoxyquinazolin-7-yl}oxy)methyl]-phenyl}-N-(ethoxycarbonyl)-S-methylsulphoximide | HCID 57788002 | 71% |
반응 단계
According to GWP 5, the reaction of N′-(2-cyano-5-{3-[(RS)-N-(ethoxycarbonyl)-S-methylsulphonimidoyl]benzyloxy}-4-methoxyphenyl)-N,N-dimethylformimidamide (100 mg, 0.22 mmol) with 3-aminobenzonitrile (31 mg, 0.26 mmol) and chromatography (silica gel, dichloromethane/methanol: 4/1) gives the desired product in 71% yield (82 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07863283B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-4abb6b63243e4567b96af808c4e41b96 |
| 출처 메모 | uspto-grants-2011_01 |