돌아가기
Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 249965생성일: 2026년 10월 25일

(RS)-N-(Ethoxycarbonyl)-S-methyl-S-[3-({[4-(2-methyl-4-pyridylamino)-6-methoxyquinazolin-7-yl]oxy}methyl)phenyl]sulphoximide → (RS)-S-[3-({[4-(2-Methyl-4-pyridylamino)-6-methoxyquinazolin-7-yl]oxy}methyl)-phenyl]-S-methylsulphoximide

https://huagongshe.com/reaction/249965

반응식

참여 물질

역할이름HCID투입량
반응물(RS)-N-(Ethoxycarbonyl)-S-methyl-S-[3-({[4-(2-methyl-4-pyridylamino)-6-methoxyquinazolin-7-yl]oxy}methyl)phenyl]sulphoximideHCID 57788005—
용매Dichloromethane methanolHCID 21226129—
생성물(RS)-S-[3-({[4-(2-Methyl-4-pyridylamino)-6-methoxyquinazolin-7-yl]oxy}methyl)-phenyl]-S-methylsulphoximideHCID 5778804879%

반응 단계

According to GWP 6, conversion of (RS)-N-(ethoxycarbonyl)-S-methyl-S-[3-({[4-(2-methyl-4-pyridylamino)-6-methoxyquinazolin-7-yl]oxy}methyl)phenyl]-sulphoximide (20 mg, 0.038 mmol) and chromatography (silica gel, dichloromethane/methanol 4/1) gives the desired product in 79% yield (14 mg).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07863283B2
출처 데이터셋uspto-grants-2011_01
ORD IDord-1bae2b9ff26449bebe67a26fe398c96a
출처 메모uspto-grants-2011_01