Piperidine → 6-Bromo-7-methoxy-3,4-dihydroquinazolin-4-one

HRID 249975

반응식

HRID 249975 반응식
[NH2:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([Br:13])=[CH:7][C:3]=1[C:4](O)=[O:5].[NH:14]1CCCC[CH2:15]1.N1C=NC=NC=1>CO>[Br:13][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][C:9]=1[O:11][CH3:12])[N:1]=[CH:15][NH:14][C:4]2=[O:5]

참가 물질

5

반응물 3

HCID 8082PiperidineHCID 92621,3,5-TriazineHCID 197019262-Amino-5-bromo-4-methoxybenzoic acid

생성물 1

HCID 1357423626-Bromo-7-methoxy-3,4-dihydroquinazolin-4-one수율 63%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-Amino-5-bromo-4-methoxybenzoic acid (1.56 g, 6.34 mmol) is dissolved in methanol (15 ml), treated with piperidine (0.063 ml, 0.63 mmol) and 1,3,5-triazine (772 mg, 9.5 mmol) and refluxed for one hour. After cooling to room temperature, the resulting crystals are filtered off with suction and washed with methanol. The desired product is obtained in 63% yield (1.01 g).

후처리

  1. temperaturerefluxed for one hour
  2. filtrationthe resulting crystals are filtered off with suction
  3. washwashed with methanol

출처 및 근거

ORD 기록
ord-1a5c152eb7c94aef8e7db017f347b61c
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863283B2

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