2-Amino-6-methylbenzothiazole → N-(6-methylbenzo[d]thiazol-2-yl)-1H-imidazole-1-carbothioamide

HRID 250004

반응식

HRID 250004 반응식
[CH3:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([NH2:9])[S:8][C:4]=2[CH:3]=1.[C:12](N1C=CN=C1)([N:14]1[CH:18]=[CH:17][N:16]=[CH:15]1)=[S:13]>C(#N)C>[CH3:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([NH:9][C:12]([N:14]3[CH:18]=[CH:17][N:16]=[CH:15]3)=[S:13])[S:8][C:4]=2[CH:3]=1

참가 물질

4

반응물 2

HCID 173352-Amino-6-methylbenzothiazoleHCID 802641,1'-Thiocarbonyldiimidazole

생성물 1

HCID 57832767N-(6-methylbenzo[d]thiazol-2-yl)-1H-imidazole-1-carbothioamide수율 62.3%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
50 °C

실험 절차

To 6-methylbenzo[d]thiazol-2-amine (1.0 g, 6.2 mmol) in acetonitrile (30 mL) was added 1,1′-thiocarbonyldiimidazole (1.44 g, 8.1 mmol). The reaction was stirred at 50° C. for 18 hours. The reaction was cooled to room temperature and the precipitate was filtered and washed with acetonitrile (2×50 mL). The yellow powder was dried in a vacuum oven (40° C.) for 1 hour to yield N-(6-methylbenzo[d]thiazol-2-yl)-1H-imidazole-1-carbothioamide (1.06 g, 3.86 mmol, 62% yield) and then used in the next step without any further purification or characterization.

후처리

  1. temperatureThe reaction was cooled to room temperature
  2. filtrationthe precipitate was filtered
  3. washwashed with acetonitrile (2×50 mL)
  4. customThe yellow powder was dried in a vacuum oven (40° C.) for 1 hour

출처 및 근거

ORD 기록
ord-b9b72e1a0d9849c38e88c58fffc5f962
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863291B2

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