Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Propionyl chloride → 4-Propionylamino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(3-methoxyphenyl)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Propionyl chloride | HCID 62324 | — |
| 반응물 | 4-amino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(3-methoxyphenyl)benzamide | HCID 19689881 | — |
| 생성물 | 4-Propionylamino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(3-methoxyphenyl)benzamide | HCID 19689948 | 90.4% |
반응 단계
Using 4-amino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(3-methoxyphenyl)benzamide (238.0 mg, 0.50 mmol) and propionyl chloride (0.077 ml, 0.60 mmol), the procedure of Inventive Example 94 was repeated to obtain 240.0 mg (90.4%) of the title compound in a yellow amorphous form.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05728835 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-a132e45c439f4a42bf67f0c0f2f018a2 |
| 출처 메모 | uspto-grants-1998_03 |