Aluminium lithium hydride → 3-Indol-1-yl-3-phenyl-propan-1-ol

HRID 250192노트

반응식

HRID 250192 반응식
C[O:2][C:3](=O)[CH2:4][CH:5]([N:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[N:12]1([CH:5]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH2:4][CH2:3][OH:2])[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13]1

참가 물질

4

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 580885583-Indol-1-yl-3-phenyl-propionic acid methyl ester

생성물 1

HCID 235559373-Indol-1-yl-3-phenyl-propan-1-ol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of 3-indol-1-yl-3-phenyl-propionic acid methyl ester (0.2 g, 0.71 mmol) in THF (5 mL) at 0° C. was added 1M LiAlH4 in THF (0.71 mL), and the mixture was stirred for 0.5 hours at room temperature. The reaction mixture was quenched by the cautious addition of Na2SO4.10H2O and the reaction mixture was stirred for another 1 h at room temperature. The mixture was filtered and the solvent was removed under vacuum. 3-Indol-1-yl-3-phenyl-propan-1-ol was obtained as a clear oil (0.166 g, 92% yield).

후처리

  1. customThe reaction mixture was quenched by the cautious addition of Na2SO4.10H2O
  2. stirringthe reaction mixture was stirred for another 1 h at room temperature
  3. filtrationThe mixture was filtered
  4. customthe solvent was removed under vacuum

출처 및 근거

ORD 기록
ord-20521d03cec147bc9bf3d6ddd096cf03
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863305B2

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