Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methane → Methyl 2-aminothiazole-5-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methane | HCID 297 | — |
| 반응물 | Thiourea | HCID 2723790 | — |
| 반응물 | Methyl 2-chloro-3-oxopropanoate | HCID 14355182 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Methyl 2-aminothiazole-5-carboxylate | HCID 238005 | 44.2% |
반응 단계
A mixture of 2.4 g of 2-chloro-3-oxo-propionic acid methyl ester (8-2), water 20 ml and 1.75 g of thiourea was refluxed for 2 hours. The mixture was cooled to room temperature and 0.25 g of norit was added and filtered. A solution of 2.5N sodium hydroxide was added to the filtrate until neutral pH. The filtration yielded 1.23 g (44%) of 2-amino-thiazole-5-carboxylic acid methyl ester (8-3).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07863306B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-af243986fd30419bacfe52c2db0020cf |
| 출처 메모 | uspto-grants-2011_01 |