참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 4-Bromo-2-nitrophenylacetic Acid | HCID 271551 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Methyl 4-bromo-2-nitrophenylacetate | HCID 15740598 | 100% |
반응 단계
A solution of (4-bromo-2-nitro-phenyl)-acetic acid (5.00 g, 19.2 mmol) in methanol (100 mL) is treated with conc. HCl (1.0 mL). The mixture is stirred at 85° C. for 16 hours and cooled to room temperature. The mixture is neutralized with aqueous Na2CO3 and concentrated under reduced pressure. The residue is extracted with ethyl acetate (50 mL×2), and the combined organic layers are dried over sodium sulfate and concentrated under reduced pressure to provide the title compound (5.27 g, 100%) as a brown solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07863302B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_01 |
|---|
| ORD ID | ord-39c68c4774554e8bb89b8a0df36ed1e9 |
|---|
| 출처 메모 | uspto-grants-2011_01 |
|---|
