Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pivaloyl chloride → 4-Pivaloylamino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(2-methoxyphenyl)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pivaloyl chloride | HCID 62493 | — |
| 반응물 | 4-amino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(2-methoxyphenyl)benzamide | HCID 19690043 | — |
| 생성물 | 4-Pivaloylamino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(2-methoxyphenyl)benzamide | HCID 19690015 | 91.3% |
반응 단계
Using 4-amino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(2-methoxyphenyl)benzamide (200.0 mg, 0.42 mmol) and pivaloyl chloride (0.062 ml, 0.51 mmol), the procedure of Inventive Example 94 was repeated to obtain 214.6 mg (91.2%) of the title compound in a colorless amorphous form.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05728835 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-6c4227a76df44fad9548989db9d0be2a |
| 출처 메모 | uspto-grants-1998_03 |