Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Guanidine → HCID 178510034, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Guanidine | HCID 3520 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 4-[[4-Chloro-6-[(2,6-dichlorophenyl)methyl]-1,3,5-triazin-2-yl]amino]benzonitrile | HCID 486423 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | HCID 178510034 | HCID 178510034 | 64.3% |
반응 단계
NaOH (0.0128 mol), 1,4-dioxane (5 ml), and guanidine (0.0128 mol) were combined and stirred at RT for 5 minutes under argon. Then, intermediate (27) (0.00128 mol) was added and the reaction mixture was stirred at RT for 16 hours. The reaction mixture was quenched with H2O, and stirred. The resulting precipitate was filtered off and the residue was stirred in refluxing methanol, cooled, and filtered, yielding 0.34 g (64.3%) of N-[4-[(4-cyanophenyl)amino]-6-[(2,6-dichlorophenyl)methyl]-1,3,5-triazin-2-yl]-guanidine (compound 20).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06858609B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-46fa65e8e380434ab77bc22111932839 |
| 출처 메모 | uspto-grants-2005_02 |