6-Chloro-2-fluoro-3-(propane-1-sulfonamido)benzoic acid → 2-Fluoro-3-(propylsulfonamido)benzoic acid

HRID 250550노트

반응식

HRID 250550 반응식
Cl[C:2]1[C:7]([C:8]([OH:10])=[O:9])=[C:6]([F:11])[C:5]([NH:12][S:13]([CH2:16][CH2:17][CH3:18])(=[O:15])=[O:14])=[CH:4][CH:3]=1>CO.[OH-].[OH-].[Pd+2]>[F:11][C:6]1[C:5]([NH:12][S:13]([CH2:16][CH2:17][CH3:18])(=[O:15])=[O:14])=[CH:4][CH:3]=[CH:2][C:7]=1[C:8]([OH:10])=[O:9]

참가 물질

4

반응물 1

HCID 580875006-Chloro-2-fluoro-3-(propane-1-sulfonamido)benzoic acid

생성물 1

HCID 580865772-Fluoro-3-(propylsulfonamido)benzoic acid

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 887Methanol용매

실험 절차

To 6-chloro-2-fluoro-3-(propane-1-sulfonylamino)-benzoic acid (115, 0.69 g, 2.3 mmol) in methanol (10 mL) was added 20% palladium hydroxide on carbon (200 mg). The reaction was stirred under hydrogen at 50 psi for 2 hours. The reaction was filtrated and concentrated to give white solid 50 that was used in the next step. MS (ESI) [M−H+]−=260.1.

후처리

  1. filtrationThe reaction was filtrated
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a26f1d32cc634727b184eae9f21705cb
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863288B2

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