1H-Pyrrolo(2,3-b)pyridine → Propane-1-sulfonic acid [3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-amide

HRID 250552

반응식

HRID 250552 반응식
[Br:1]C1C=C2C(=CC=1)NN=C2.ClC1C=C2C(=NC=1)NC=C2.FC1C=C2C(=NC=1)NC=C2.N1C2C(=CC=CN=2)C=C1.[F:40][C:41]1[C:46]([C:47]([C:49]2[C:57]3[C:52](=[N:53][CH:54]=[C:55](F)[CH:56]=3)[NH:51][CH:50]=2)=[O:48])=[CH:45][CH:44]=[CH:43][C:42]=1[NH:59][S:60]([CH2:63][CH2:64][CH3:65])(=[O:62])=[O:61].FC1C(C(C2C3C(=NC=CC=3)NC=2)=O)=CC=CC=1NS(CCC)(=O)=O>>[Br:1][C:55]1[CH:56]=[C:57]2[C:49]([C:47]([C:46]3[C:41]([F:40])=[C:42]([NH:59][S:60]([CH2:63][CH2:64][CH3:65])(=[O:62])=[O:61])[CH:43]=[CH:44][CH:45]=3)=[O:48])=[CH:50][NH:51][C:52]2=[N:53][CH:54]=1

참가 물질

7

반응물 6

HCID 92221H-Pyrrolo(2,3-b)pyridineHCID 7619295-bromo-1H-indazoleHCID 207844625-Fluoro-1H-pyrrolo[2,3-b]pyridineHCID 242292135-Chloro-1H-pyrrolo[2,3-b]pyridineHCID 58087704propane-1-sulfonic acid [2-fluoro-3-(5-fluoro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-phenyl]-amideHCID 58087847propane-1-sulfonic acid [2-fluoro-3-(1H-pyrrolo[2,3-b]pyridin-3-carbonyl)-phenyl]-amide

생성물 1

HCID 58086733Propane-1-sulfonic acid [3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-amide

실험 절차

Using the protocol of Scheme 14, substituting 5-bromo-azaindole with either 5-chloro-7-azaindole (80, prepared as described in Example 9), 5-fluoro-7-azaindole (81, prepared as described in Example 9) or 7-azaindole in Step 6, propane-1-sulfonic acid [3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-amide P-1013 (MS (ESI) [M−H+]−=394.1), propane-1-sulfonic acid [2-fluoro-3-(5-fluoro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-phenyl]-amide P-1028 (MS (ESI) [M−H+]−=378.1), and propane-1-sulfonic acid [2-fluoro-3-(1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-phenyl]-amide P-1056 (MS (ESI) [M+H+]+=362.2) were prepared, respectively;

후처리

  1. custom(MS (ESI) [M+H+]+=362.2) were prepared

출처 및 근거

ORD 기록
ord-0292e2944f1e4bd786619c33751fa9a7
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863288B2

연결된 노트

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