Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Chloro-1H-pyrrolo[2,3-b]pyridine → Thiophene-2-sulfonic acid [3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Chloro-1H-pyrrolo[2,3-b]pyridine | HCID 24229213 | — |
| 반응물 | N-(2,4-difluoro-3-formylphenyl)propane-2-sulfonamide | HCID 58086031 | — |
| 반응물 | Thiophene-2-sulfonic acid (2,4-difluoro-3-formyl-phenyl)-amide | HCID 58086492 | — |
| 생성물 | Thiophene-2-sulfonic acid [3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-amide | HCID 58086197 | — |
반응 단계
was prepared using the protocol of Steps 3 and 4 of Scheme 17, substituting 5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridine 89 with 5-chloro-7-azaindole 80 (see Example 9) and propane-2-sulfonic acid (2,4-difluoro-3-formyl-phenyl)-amide 60 with thiophene-2-sulfonic acid (2,4-difluoro-3-formyl-phenyl)-amide 512 (see Example 21) in Step 3. MS (ESI) [M+H+]+=451.9.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07863288B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-8de5a0b9dcef4c8c99d30989892eeb95 |
| 출처 메모 | uspto-grants-2011_01 |