Dimethylformamide → (+/-)-8-Methyl-5-(4-nitrophenyl)-7-(2-thiazolyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

참여 물질

역할	이름	HCID	투입량
반응물	Dimethylformamide	HCID 6228	—
반응물	Ethane, 2-bromo-1,1-diethoxy-	HCID 74852	—
반응물	(+/-)-8-Methyl-5-(4-nitrophenyl)-7-thiocarbamoyl-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine	HCID 12137394	—
용매	Water	HCID 962	—
생성물	(+/-)-8-Methyl-5-(4-nitrophenyl)-7-(2-thiazolyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine	HCID 12137420	80%

반응 조건

온도	80 °C

반응 단계

A mixture of 1.00 g (2.60 mmol) of the starting material I, 2.54 g (12.89 mmol) of bromoacetaldehyde diethyl acetal and 10 ml of dimethylformamide was stirred at 80° C. for 40 min. Then the reaction mixture was diluted with water and the crude product obtained was recrystallized from ethanol to yield 0.85 g (80%) of the title compound. Mp.: 145-150° C.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06858605B2
출처 데이터셋	uspto-grants-2005_02
ORD ID	ord-d6fbdcbbe9454367a6b64eb88f7e508c
출처 메모	uspto-grants-2005_02