Dimethylformamide → (+/-)-7-(4,5-Dihydro-4-oxo-thiazol-2-yl)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

참여 물질

역할	이름	HCID	투입량
반응물	Dimethylformamide	HCID 6228	—
반응물	Methyl bromoacetate	HCID 60984	—
반응물	(+/-)-8-Methyl-5-(4-nitrophenyl)-7-thiocarbamoyl-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine	HCID 12137394	—
용매	Water	HCID 962	—
생성물	(+/-)-7-(4,5-Dihydro-4-oxo-thiazol-2-yl)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine	HCID 12137431	91%

반응 조건

온도	85 °C

반응 단계

A mixture of 1.00 g (2.6 mmol) of the starting material I, 1.19 g (7.78 mmol) of methyl bromoacetate and 10 ml of dimethylformamide was stirred at 80-90° C. for 1 h. After diluting with water the obtained crude product was purified by refluxing in methanol to yield 1.00 g (91%) of the title compound; Mp.: 218-220° C.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06858605B2
출처 데이터셋	uspto-grants-2005_02
ORD ID	ord-334775d56d9c4fd4b1e9df895da9cc7d
출처 메모	uspto-grants-2005_02