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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Sodium Iodide → (+/-)-7-(4,5-Dihydro-oxazol-2-yl)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

HRID 25071
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인쇄 미리보기

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HRID 25071 반응식
Cl[CH2:2][CH2:3][NH:4][C:5]([N:7]1[CH:13]([CH3:14])[CH2:12][C:11]2[CH:15]=[C:16]3[O:21][CH2:20][O:19][C:17]3=[CH:18][C:10]=2[C:9]([C:22]2[CH:27]=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][CH:23]=2)=[N:8]1)=[O:6].C(=O)([O-])[O-].[K+].[K+].[I-].[Na+].CN(C)C=O>O>[O:6]1[CH2:2][CH2:3][N:4]=[C:5]1[N:7]1[CH:13]([CH3:14])[CH2:12][C:11]2[CH:15]=[C:16]3[O:21][CH2:20][O:19][C:17]3=[CH:18][C:10]=2[C:9]([C:22]2[CH:27]=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][CH:23]=2)=[N:8]1
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참가 물질

6

반응물 4

HCID 5238Sodium IodideHCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 12137418(+/-)-8-Methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carboxylic acid (2-chloroethyl)-amide

생성물 1

HCID 22565447(+/-)-7-(4,5-Dihydro-oxazol-2-yl)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
수율 76.4%

시약·촉매·용매 1

HCID 962Water용매

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온도
105 °C

실험 절차

A mixture of 1.43 g (3.32 mmol) of the starting material XXV, 1.38 g (9.98 mmol) of anhydrous potassium carbonate, 0.24 g (1.60 mmol) of sodium iodide and 24 ml of dimethylformamide was stirred at 100-110° C. for 4 h. Then the mixture was diluted with water and the precipitated crude product was recrystallized from ethanol to yield 1.00 g (76%) of the title compound; Mp.: 194-196° C.

후처리

  1. customthe precipitated crude product
  2. customwas recrystallized from ethanol

출처 및 근거

ORD 기록
ord-bbcd50fcc25f4f5c91fcd5d73bcc8b28
출처 데이터셋
uspto-grants-2005_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06858605B2

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