Isobutylamine → HCID 86067101, 화합물

HRID 250732노트

반응식

HRID 250732 반응식
[CH2:1]([NH2:5])[CH:2]([CH3:4])[CH3:3].[CH3:6][N:7]([O:20][CH3:21])[C:8](=[O:19])[C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[C:11](F)[CH:10]=1>C(#N)C>[CH3:6][N:7]([O:20][CH3:21])[C:8](=[O:19])[C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[C:11]([NH:5][CH2:1][CH:2]([CH3:4])[CH3:3])[CH:10]=1

참가 물질

4

반응물 2

HCID 6558IsobutylamineHCID 577580833-Fluoro-N-methoxy-N-methyl-4-nitrobenzamide

생성물 1

HCID 86067101HCID 86067101, 화합물수율 90%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Add isobutylamine (8.7 mL) dropwise to a solution of N-[methyl]-N-[methoxy]-3-fluoro-4-nitrobenzamide (2 g, 8.77 mmol) in 80 mL dry acetonitrile at 0° C. Stir the resulting orange solution at room temperature over night. Concentrate under reduced pressure to provide the desired compound (90%).

후처리

  1. concentrationConcentrate under reduced pressure

출처 및 근거

ORD 기록
ord-c86c433a2cee4afc9150c90fcaf4ff36
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863310B2

반응 노트

불러오는 중…