Methylamine → 1-Isobutyl-2-amino-6-(methyliminomethyl)-1H-benzimidazole
반응식
[CH3:1][NH2:2].[CH2:3]([N:7]1[C:11]2[CH:12]=[C:13]([CH:16]=O)[CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1[NH2:18])[CH:4]([CH3:6])[CH3:5]>CN(C)C=O>[CH2:3]([N:7]1[C:11]2[CH:12]=[C:13]([CH:16]=[N:2][CH3:1])[CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1[NH2:18])[CH:4]([CH3:6])[CH3:5]참가 물질
4
실험 절차
Add methylamine (3.0 mL, 6 mmol, 2M in tetrahydrofuran) to a solution 1-isobutyl-2-amino-6-formylbenzimidazole (475 mg, 2.19 mmol) in dimethylformamide (5 mL). Stir at room temperature for 18 hours. Concentrate under reduced pressure to provide the title compound (503 mg).
후처리
- concentrationConcentrate under reduced pressure
출처 및 근거
- ORD 기록
- ord-4e13cb2630424527b0ce4bde33ce3931
- 출처 데이터셋
- uspto-grants-2011_01
- 특허 번호
- US07863310B2
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