m-Chloroperbenzoic acid → 3-cyclohexyl-2-methylpyridine N-oxide
반응식
[CH:1]1([C:7]2[C:8]([CH3:13])=[N:9][CH:10]=[CH:11][CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C1C=C(Cl)C=C(C(OO)=[O:22])C=1>C(Cl)Cl>[CH:1]1([C:7]2[C:8]([CH3:13])=[N+:9]([O-:22])[CH:10]=[CH:11][CH:12]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1참가 물질
4
실험 절차
A solution of 3-cyclohexyl-2-methylpyridine (170 mg, 1.0 mmol), in CH2Cl2 (5 mL) was treated with MCPBA (0.33 g, 1.9 mmol) for 18 hours. The solution was then washed with saturated NaHCO3 solution (5 mL), the phases separated, and the aqueous extracted with CH2Cl2 (2×10 mL). The combined organic phases were then dried (Na2SO4), filtered, and concentrated to afford crude 3-cyclohexyl-2-methylpyridine N-oxide as a white solid (0.215 g) which was used immediately in the next reaction.
후처리
- washThe solution was then washed with saturated NaHCO3 solution (5 mL)
- customthe phases separated
- extractionthe aqueous extracted with CH2Cl2 (2×10 mL)
- dry with materialThe combined organic phases were then dried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-311cde94ceb6458e91b8fa5f06145490
- 출처 데이터셋
- uspto-grants-2011_01
- 특허 번호
- US07863293B2
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