Potassium Carbonate → HCID 67272225, 화합물
반응식
[CH:1]1([C:7]2[C:8]([CH2:13][O:14]C(=O)C)=[N:9][CH:10]=[CH:11][CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C([O-])([O-])=O.[K+].[K+]>CO>[CH:1]1([C:7]2[C:8]([CH2:13][OH:14])=[N:9][CH:10]=[CH:11][CH:12]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1참가 물질
4
실험 절차
A solution of the above ester (0.23 g, 1.0 mmol) in anhydrous MeOH (5 mL) was treated with K2CO3 (0.27 g, 2.0 mmol) and stirred at room temperature for 3.5 h. The mixture was concentrated under reduced pressure and water (5 ml) was added. The aqueous solution was then extracted with CH2Cl2 (3×10 mL) and the combined organic phases dried (Na2SO4), filtered, and concentrated under reduced pressure. This gave the desired (3-cyclohexyl-pyridin-2-yl)-methanol as a brown liquid (0.15 g, 79%) that was used immediately in the next reaction.
후처리
- concentrationThe mixture was concentrated under reduced pressure and water (5 ml)
- additionwas added
- extractionThe aqueous solution was then extracted with CH2Cl2 (3×10 mL)
- dry with materialthe combined organic phases dried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-0fffc26a6dba48e980f904b354d7065e
- 출처 데이터셋
- uspto-grants-2011_01
- 특허 번호
- US07863293B2
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